李 蓬

2020-07-15 16:27:10
    

李蓬 博士

教授,中国科学院院士,发展中国家科学院(TWAS)院士,国家自然科学基金委生命学部主任(兼)


1987年 北京师范大学 学士

1995年 美国加州大学圣地亚哥分校 博士

1995-1996  新加坡国立大学分子与细胞生物学研究所 博士后

1996-1997  美国达拉斯德州大学西南医学中心Howard Hughes医学研究所 博士后

1997-2003 新加坡分子和细胞生物学研究所 助理教授及研究室主任

2003-2006 香港科技大学生物系,助理教授&副教授(获终身制)

2006-至今 清华大学生命科学学院,教授,博士生导师

 

●  研究兴趣、领域:


集中于糖脂代谢的研究,包括脂滴生物学,肥胖、糖尿病和脂肪肝等代谢性疾病发生发展的分子机制,主要探究调控脂滴融合、脂滴-内质网、脂滴-线粒体互作的信号分子和蛋白质机器的角度,阐明它们在肥胖、糖尿病和脂肪肝等代谢性疾病发生发展中的作用。


●  代表性论文:


1. Lyu X, Wang J, Wang J, Yin Y S, Zhu Y, Li L L, Huang S, Peng S, Xue B, Liao R, Wang S Q, Long M, Wohland T, Chua B T, Sun Y, Li P, Chen X W, Xu L, Chen F-J*, Li P*. (2021) A gel-like condensation of Cidec generates lipid-permeable plates for lipid droplet fusion. Dev Cell 56:2592–606

2. Du X, Zhou L, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P*, and Yang H* (2020) ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. J Cell Biol. 219: pii: e201905162.

3. Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X*, Li P* (2019) Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 38:e100156.

4. Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P* (2019) The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition. Cell Rep. 28:3406-22

5. Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P* (2018) Rab18 promotes lipid droplet growth by tethering the ER to lipid droplets through SNARE and NRZ interactions. J Cell Biol. 217:975-95.

6. Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P*, Xu L* (2018) Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes. Diabetes 67:1935-48.

7. Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P* (2017) HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. J Clin Invest. 127: 1353-69.

8. Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P* (2015) Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice. Nat Commum. 6, 5949.

9. Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P* (2014) Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth. Dev Cell 30: 378-93.

10. Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M and Li P* (2013) Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes. Nat Commum. 4: 1594

11. Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P* (2012) Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 18: 235-43.

12. Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P* (2011) Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol. 195: 953-63.

13. Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P* (2009) Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab. 9: 177-90.

14. Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P* (2008) Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 27: 1537-48.

15. Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P* (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 35: 49-56.


●  荣誉、奖励及参加学术团体的情况:


何梁何利基金生命科学领域科学与技术进步奖,2012年

中国生物物理学会副理事长,2017年至今

中国生物物理学会代谢生物学分会理事长,2017年至今

Cell Metabolism 编委,2020年6月至今

Life Metabolism 杂志主编


●  联系方式:


通信地址:北京市海淀区清华大学生命科学学院(100084)
电话:010-62797133
Email:li-peng@mail.tsinghua.edu.cn
Fax:86-10-62797121