潘俊敏 博士

教授

1986年／河北师范大学／学士

1989年／中科院水生所／硕士

1996年／德国弗莱堡大学／博士

1997－1999年／美国西南医学中心／博士后

2000－2006年／美国西南医学中心／研究助理教授

2006年-至今／清华大学生命科学学院／教授

 

●  研究兴趣、领域：

主要有两个研究方向，纤毛生物学与微藻合成生物学。纤毛行使细胞运动和信号传导的功能，其结构或功能缺陷可导致人类疾病或发育异常，统称为“纤毛病”。我们聚焦模式生物衣藻和动物细胞，利用遗传，细胞，生化和各种组学手段研究纤毛运动、发生的分子机理，研究成果对纤毛相关疾病的发病机制、医疗诊断和治疗提供科学依据和借鉴。在微藻合成生物学方面，主要是开发微藻合成生物学工具以及研发潜在的高价值附加产物。

  

●  代表性论文：

1. Wang Z., He R., Liu Q., Snell W. J.*, Cao, M.*, Pan, J.* 2025. A lipid flippase shapes the ciliary membrane and is essential for ciliogenesis. Curr Biol. 35:1-9. https://doi.org/10.1016/j.cin.2025.10.014

2. Zhang Y., Yang X., Pan J.*. 2025. Chlamydomonas protein kinase MAK phosphorylates FAP256/CEP104 and regulates axonemal microtubule assembly. PNAS. 22:e2503094122

3. Xu J*, Zhang Y., Pan, J.* 2025. Primary Cilia- Mediated Hedgehog Signaling Regulates Cell Fate During ER Stress Induced Life or Death Decisions. FASEB J. 39:e70982.

4. Li X., Zhang, Y., Wen X., Pan J.* 2024. Utilizing codon degeneracy in the design of donor DNA for CRISPR/Cas9-mediated gene editing to streamline the screening process for single amino acid mutations. Plant J. 119(4):2133-2143.

5. Junhao Huang, Hui Tao, Jikun Chen, Yang Shen, Jianlin Lei, Junmin Pan*, Chuangye Yan* and Nieng Yan*. 2024. Structure-guided discovery of protein and glycan components in native mastigonemes. Cell. 187:1733-1744.

6. Pan J. 2023. Ciliary disassembly. In The Chlamydomonas Sourcebook. Volume 3 – Cell Motility and Behavior (ed. S. Dutcher), pp. 357-372，Oxford, UK: Elsevier, Inc.

7. Wang L, Li X, Liu G, Pan J.* 2022. FBB18 participates in preassembly of almost all axonemal dyneins independent of R2TP complex. PLos Genet. 18(8):e1010374.

8. Zhu X, Wang J, Li S, Lechtreck K, Pan J.* 2021. IFT54 directly interacts with kinesin-II and IFT dynein to regulate anterograde intraflagellar transport. EMBO J 40: e105781.

9. Li S, Wan KY, Chen W, Tao H, Liang X*, Pan J.* 2020. Functional exploration of heterotrimeric kinesin-II in IFT and ciliary length control in Chlamydomonas. eLife 9:e58868.

10. Liang Y, Zhu X, Wu Q, Pan J.* 2018. Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly. Curr Biol. 28(15), 2429-2435.

11. Zhu B, Zhu X, Wang L, Liang Y, Feng Q, Pan J.* 2017. Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis. PLoS Genet. 13(2):e1006627.

12. Hu J, Liang Y, He W, Pan J.* 2015. Cilia disassembly with two distinct phases of regulation. Cell Reports 10, 1803-1810.

13. Liang Y, Pang Y, Wu Q, Hu Z, Han X, Xu Y, Deng H, Pan J.* 2014. FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. Dev Cell. 30, 585-597.

14. Cao M, Meng D, Wang L, Bei S, Snell WJ*, Pan J.* 2013. Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar length. PNAS, 110, 12337-42.

 

●  荣誉、奖励及参加学术团体的情况：

现担任微生物学会自养微生物专业委员会副主任，eLife, Cells, Scientific Reports, Model Organism Research, 中国细胞生物学学报编委。

●  联系方式：

电话：+86-10-62771864

邮箱： panjunmin@tsinghua.edu.cn

通讯地址： 北京海淀清华大学生命学院, 邮编100084